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Product Details

PD-150606 | Calpain Inhibitor

PD-150606 (179528-45-1) is a selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices1. PD-150606 displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death2. Some protective effects may be due to inhibition of MMP activity3.

References/Citations
1) Wang et al. (1996), An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective; Proc. Natl. Acad. Sci. USA, 93 6687
2) Waters et al. (1997), Calpains mediate calcium and chloride influx during the late phase of cell injury; J. Pharmacol. Exp. Therap., 283 1177
3) Ali et al. (2012), Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity; Biochem. Biophys. Res. Commun., 423 1

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PD-150606 | 179528-45-1 | Structure | Supplier

Catalog#  10-1515

$69.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
179528-45-1
Catalog Number:
10-1515
Activity:
Calpain Inhibitor
Chemical Name:
(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid
Molecular Weight:
306.12
Molecular Formula:
C9H7IO2S
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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