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Product Details

PD-98059 | MEK inhibitor

PD-98059 (167869-21-8) is an inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7μM).1,2 PD-98059 accelerates differentiation of RAW264.7 cells into osteoclast-like cells.3 Mimics BMP4 in supporting self renewal of embryonic stem cells.4

References/Citations
1) Alessi et al. (1995), PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo; J. Biol. Chem., 270 27489
2) Dudley et al. (1995), A synthetic inhibitor of the mitogen-activated protein kinase cascade; Proc. Natl. Acad. Sci., 92 7686
3) Hotokezaka et al. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells; J. Biol. Chem., 277 47366
4) Xiaoxia et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways; Proc. Natl. Acad. Sci. USA 101 6027

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Catalog#  10-2159

$55.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
167869-21-8
Catalog Number:
10-2159
Activity:
MEK inhibitor
Alternate Names:
2'-Amino-3'-methoxyflavone
Chemical Name:
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Molecular Weight:
267.29
Molecular Formula:
C16H13NO3
Solubility:
Soluble in DMSO (up to 6 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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