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Product Details

PD173074 | FGFR inhibitor

PD173074 (219580-11-7)is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1 (IC50 values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem cell self renewal.2,3

References/Citations
1 Bansal et al. (2003), Specific inhibitor of FGF receptor signaling: FGF-2 mediated effects on proliferation, differentiation and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells; J. Neurosci. Res., 74 486
2) Kim et al. (2012), Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesencymal stem cell constructs; Biotechnol. Prog., 28 1384
3) Zaragosi et al. (2006), Autocrine fibroblast growth factor 2 signaling is critical for self renewal of human multipotent adipose-derived stem cells; Stem Cells, 24 2412

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Catalog#  10-4505

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
219580-11-7
Catalog Number:
10-4505
Activity:
FGFR inhibitor
Chemical Name:
1-t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl)urea
Molecular Weight:
523.67
Molecular Formula:
C28H41N7O3
Solubility:
Soluble in DMSO.
Physical Properties:
Yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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