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PDE4 inhibitor for atopic dermatitisPDE4 inhibitor for atopic dermatitisPDE4 inhibitor for atopic dermatitisPDE4 inhibitor for atopic dermatitis
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    • Biochemical Targets
      • Autophagy
      • Bioactive Lipids
      • Cellular Metabolism
      • Cellular trafficking
      • Cytoskeleton
      • DNA Damage/Repair
      • Epigenetics
      • Gene regulation
      • GPCRs
      • Ions and other channels
      • Kinases
      • Mitochondria
      • Nuclear receptors
      • Transcription factors
      • Ubiquitin/Proteasome
      • View All
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      • Cancer
      • Cardiovascular
      • Cell Cycle
      • Cellular Senescence
      • Cellular Stress
      • Circadian clock
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      • Immunology
      • Inflammation
      • Neurodegeneration
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      • Stem cells
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PDE4 inhibitor for atopic dermatitis

Published by Focus Biomolecules on February 19, 2026

FOCUS on new drug approvals. On February 12th the FDA granted approval for Acrotech Biopharma’s Difamilast (Adquey) for mild to moderate atopic dermatitis. The approval marks a significant advancement in dermatology care, providing the first nonsteroidal agent for treating this chronic inflammatory skin condition. Difamilast is a phosphodiesterase 4 (PDE4) inhibitor formulated as a 1% topical ointment. The drug inhibits all PDE4 subtypes and offers a new therapeutic approach for managing the inflammation and pruritis of eczema.

Focus Biomolecules offers Difamilast for research applications. Contact us for more information.

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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