Pemetrexed 2Na | Multitargeted antifolate

Pemetrexed (357166-29-1) is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5

 

References/Citations
1) Shih et al. (1997), LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes; Cancer Res. 57 1116
2) Hanauske et al. (2001), Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors; Oncologist 6 363
3) Rothbart et al. (2010), Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas; Cancer Res. 70 10299
4) Qin et al. (2019), AMPK activation induced in pemetrexed-treated cells is associated with development of drug resistance independently of target enzyme expression; Mol. Oncol. 13 1419
5) Li et al. (2019), Pemetrexed exerts anticancer effects by inducing G0/G1-phase cell cycle arrest and activating the NOXA/Mcl-1 axis in human esophageal squamous cell carcinoma cells; Oncol. Lett. 17 1851

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

10 mg, 50 mg

Reviews

There are no reviews yet.

Be the first to review “Pemetrexed 2Na | Multitargeted antifolate”

Your email address will not be published. Required fields are marked *

Product Inquiry

CAS:
357166-29-1
Catalog Number:
10-2162
Activity:
Multi-targeted antifolate
Chemical Name:
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt
Molecular Weight:
597.49
Molecular Formula:
C20H19N5O6 • 2Na • 7H2O
Solubility:
Soluble in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC and HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.
Shipping Code:
RT

Pemetrexed 2Na | Multitargeted antifolate

$40.00$160.00

CAS:
357166-29-1
Catalog Number:
10-2162
Activity:
Multi-targeted antifolate
Chemical Name:
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt
Molecular Weight:
597.49
Molecular Formula:
C20H19N5O6 • 2Na • 7H2O
Solubility:
Soluble in Water (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC and HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 31month.
Shipping Code:
RT
  • 10 mg
  • 50 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.