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PF-9366 | Methionine adenosyltransferase 2A inhibitor

PF-9366 (72882-78-1) is an allosteric inhibitor (IC50 = 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1 It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 µM and 225 nM respectively.

References/Citations
1) Quinlan et al. (2017), Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol., 13 785

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

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CAS:
72882-78-1
Catalog Number:
10-4635
Activity:
Methionine adenosyltransferase 2A inhibitor
Chemical Name:
2-(7-Chloro-5-phenyl)-[1,2,4]triazolo[4,3-a]quinoline-1-yl)-N,N,dimethylethanamine
Molecular Weight:
350.85
Molecular Formula:
C20H19ClN4
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

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PF-9366 | Methionine adenosyltransferase 2A inhibitor

$70.00 – $265.00

CAS:
72882-78-1
Catalog Number:
10-4635
Activity:
Methionine adenosyltransferase 2A inhibitor
Chemical Name:
2-(7-Chloro-5-phenyl)-[1,2,4]triazolo[4,3-a]quinoline-1-yl)-N,N,dimethylethanamine
Molecular Weight:
350.85
Molecular Formula:
C20H19ClN4
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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Products PF-9366 | Methionine adenosyltransferase 2A inhibitor