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Product Details

PFK15 | Phosphofructo-2-kinase (PFKFB3) inhibitor

PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).  PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50 = 207 nM) without inhibiting 96 other kinases.1 PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth in vitro and in vivo. PFK15 has been shown to inhibit tumor growth in various cancer models.2,3

References/Citations

1) Clem et al. (2013), Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer; Mol. Cancer Ther. 12 1461
2) Zhu et al. (2016), PFK15,a Small Molecule Inhibitor of PFKFB3, Induces Cell Cycle Arrest, Apoptosis and Inhibits Invasion in Gastric Cancer; PLoS One 11 e0163768
3) Li et al. (2017), Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma; J. Exp. Clin. Cancer Res. 36 7

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Catalog#  10-4580-0005

$45.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
4382-63-2
Catalog Number:
10-4580
Activity:
Phosphofructo-2-kinase (PFKFB3) inhibitor
Chemical Name:
1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Molecular Weight:
260.29
Molecular Formula:
C17H12N2O
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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