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Phenoxybenzamine HCl | Calmodulin antagonist

Phenoxybenzamine HCl (63-92-3) binds to and inhibits calmodulin in a calcium-dependent and irreversible manner (IC50= ca. 1 μM)1. A classical irreversible α adrenergic antagonist2. Phenoxybenzamine HCl is a useful tool for irreversible inhibition of calmodulin. Cell permeable.

References/Citations
1) Earl et al. (1984), Interaction of alpha adrenergic antagonists with calmodulin; Life Sci., 355 525
2) Frang et al. (2001), Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors; J. Biol. Chem., 276 31279
3) James et al. (2009), Inhibition of nitric oxide-activated guanylylcyclase by calmodulin antagonists; Br. J. Pharmacol., 158 1454

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Phenoxybenzamine HCl | 63-92-3 | Structure | Supplier

Catalog#  10-1237

$30.00
Quantity
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CAS:
63-92-3
Catalog Number:
10-1237
Activity:
Calmodulin antagonist
Chemical Name:
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride
Molecular Weight:
340.29
Molecular Formula:
C18H22ClNO HCl
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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