Phomopsin A | Microtubule binding agent

CAS:
 64925-80-0
Catalog Number:
 10-2984
Phomopsin A chemical structure

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Phomopsin A (64925-80-0) is a novel fungal metabolite produced by Phomopsis sp. which may contaminate food and feed stocks.1 It binds to tubulin at the vinca site.2,3 Phomopsin interferes with intracellular transport, inhibits eukaryotic cell proliferation, and promotes cell death by suppressing microtubule dynamics.4

References/Citations:

  1. Van Egmond et al. (2007), Regulations relating to mycotoxins in food: perspectives in a global and European context; Anal. Bioanal. Chem. 389 147
  2. Chengyong et al. (2021), The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design; FEBS Lett. 595 195
  3. Naaz et al. (2019), Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains; Eur. J. Med. Chem. 171 310
  4. Steinmetz et al. (2018), Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton; Trends Cell Biol. 28 776
64925-80-0, nsc381839, Phomopsin A, Phomopsin A supplier, Phomopsin supplier
CAS:
64925-80-0
Catalog Number:
10-2984
Activity:
Microtubule binding agent
Chemical Names:
Natural product isolated from Phomopsis sp
Alternate Name:
NSC381839
Molecular Weight:
789.24
Molecular Formula:

C36H45ClN5O12

Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
White to off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Phomopsin A (64925-80-0) is a novel fungal metabolite produced by Phomopsis sp. which may contaminate food and feed stocks.1 It binds to tubulin at the vinca site.2,3 Phomopsin interferes with intracellular transport, inhibits eukaryotic cell proliferation, and promotes cell death by suppressing microtubule dynamics.4

References/Citations:

  1. Van Egmond et al. (2007), Regulations relating to mycotoxins in food: perspectives in a global and European context; Anal. Bioanal. Chem. 389 147
  2. Chengyong et al. (2021), The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design; FEBS Lett. 595 195
  3. Naaz et al. (2019), Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains; Eur. J. Med. Chem. 171 310
  4. Steinmetz et al. (2018), Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton; Trends Cell Biol. 28 776

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