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Product Details

Picropodophyllotoxin | IGF1R inhibitor

Picropodophyllotoxin (477-47-4) is a potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP.1 Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM.1 Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 μM.2 Exhibits antiangiogenic activitiy.3 Picropodophyllotoxin attenuates intimal hyperplasia after vascular injury.4 Active in vivo.

References/Citations
1) Girnita et al. (2004), Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth; Cancer Res., 64 236
2) Girnita et al. (2006), The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of iveal melanoma cells; Clin. Cancer Res., 12 1383
3) Menu et al. (2007), Targeting the IGF-1R using picropodophyllin in therapeutical 5T2MM mouse model of multiple myeloma: beneficial effects on tumor growth, angiogenesis, bone disease and survival; Int. J. Cancer, 121 1857
4) Razuvaev et al. (2007), The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling; J. Vasc. Surg., 46 108

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Focus Biomolecules supplier, chemical structure of Picropodophyllotoxin | IGF-1R inhibitor | CAS 477-47-4

Catalog#  10-2189

$80.00
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CAS:
477-47-4
Catalog Number:
10-2189
Activity:
IGF1R inhibitor
Chemical Name:
(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Molecular Weight:
414.42
Molecular Formula:
C22H22O8
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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