Pimaricin (7681-93-8) is a polyene macrolide topical antifungal agent. Specifically binds to ergosterol and inhibits fungal growth, not by forming pores in the plasma membrane (as is the case with other polyene macrolides such as amphotericin B)1 but by inhibition of amino acid and glucose transport2. Pimaricin blocks vacuole fusion at the priming phase via binding to ergosterol3.
1) te Welscher et al. (2008), Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane; J. Biol. Chem., 283 6393
2) te Welscheri et al. (2012), Polyene antibiotic that inhibits membrane transport proteins; Proc. Natl. Acad. Sci. USA., 109 11156
3) te Welscher et al. (2010), Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol; Antimicrob. Agents Chemother., 54 2618