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Product Details

Pimaricin (Natamycin) | Antifungal Polyene macrolide

Pimaricin (7681-93-8) is a polyene macrolide topical antifungal agent. Specifically binds to ergosterol and inhibits fungal growth, not by forming pores in the plasma membrane (as is the case with other polyene macrolides such as amphotericin B)1 but by inhibition of amino acid and glucose transport2. Pimaricin blocks vacuole fusion at the priming phase via binding to ergosterol3.

References/Citations
1) te Welscher et al. (2008), Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane; J. Biol. Chem., 283 6393
2) te Welscheri et al. (2012), Polyene antibiotic that inhibits membrane transport proteins; Proc. Natl. Acad. Sci. USA., 109 11156
3) te Welscher et al. (2010), Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol; Antimicrob. Agents Chemother., 54 2618

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Catalog#  10-2742

$48.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
7681-93-8
Catalog Number:
10-2742
Activity:
Antifungal Polyene macrolide
Alternate Names:
Natamycin
Chemical Name:
Fermentation product from Streptomyces chattanoogensis
Molecular Weight:
665.74
Molecular Formula:
C3347NO13
Solubility:
Soluble in DMSO (up to 7 mg/ml). Only slightly soluble in Ethanol (less than 1 mg/ml).
Physical Properties:
Cream colored solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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