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Product Details

Pinacidil | Potassium channel opener

Pinacidil (85371-64-8) activates ATP-dependent potassium channels.1,2 Induces vascular relaxation and antihypertensive effects.3  Prevents the loss of mitochondrial inner membrane potential, protecting cerebellar granule neurons from apoptosis induced by oxidative stress.4 Displays protective effects in Parkinson’s disease models5 and cerebral ischemia-reperfusion6.

References/Citations

1) Hermsmeyer et al. (1988), Pinacidil actions on ion channels in vascular muscle; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S17
2) Gollasch et al. (1995), Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells; J. Phamracol. Exp. Therap., 275 681
3) Cohen & Kurz (1988), Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S5
4) Teshima et al. (2003), Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress; Stroke, 34 1796
5) Xie et al. (2010), K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS protection; J. Neurosci. Res., 88 428
6) Zhang et al. (2008), Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats; Neurosci. Bull., 24 7

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Catalog#  10-2856-0010

$30.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
85371-64-8
Catalog Number:
10-2856
Activity:
Potassium channel opener
Chemical Name:
(+/-)-N-Cyano-N’-4-pyridinyl-Nα-(1,2,2-trimethylpropyl)guanidine monohydrate
Molecular Weight:
263.34
Molecular Formula:
C13H19N5 • H2O
Solubility:
Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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