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Piperlongumine | Glutathione sponge / Increases ROS levels

Piperlongumine (20069-09-4) elevates cellular levels of reactive oxygen species selectively in cancer cell lines1. Irreversible glutathionylation leading to depletion of cellular glutathione is associated with its cellular toxicity2. Piperlongumine does not appear to have any effect on normal cells. Displays anti-tumor effects in a mouse xenograft tumor model as well as in spontaneously formed malignant breast tumors in mice1. Elevation of ROS levels in response to piperlongumine may be due to inhibition of ubiquitin-proteasome system at a pre-proteasomal step.3

1) Raj et al. (2011), Selective killing of cancer cells by a small molecule targeting the stress response to ROS; Nature, 475 7355
2) Adams et al. (2012), Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs; Proc. Natl. Acad. Sci. USA, 109 15115
3) Jarvius et al. (2013), Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells; Biochem. Biophys. Res. Commun. 10.1016

Focus Biomolecules cell signaling tech supplier, chemical structure of Piperlongumine | Glutathione sponge | CAS 20069-09-4

Catalog#  10-2377

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Catalog Number:
Glutathione sponge / Increases ROS levels
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Cream-colored solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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