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Product Details

PIT-1 | PH domain antagonist

PIT-1 (53501-41-0) is a PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 mM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 mM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.

References/Citations

1) Maio et al. (2010), Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PI3) binding to pleckstin homology domains; Proc. Natl. Acad. Sci. USA, 107 20126
2) McNamare and Degterev (2011), Small-molecule inhibitor of the PI3K signaling network; Future Med. Chem., 3 549

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PIT-1 | 53501-41-0 | Structure | Supplier

Catalog#  10-1192-0010

$35.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
53501-41-0
Catalog Number:
10-1192
Activity:
PH domain antagonist
Chemical Name:
N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Molecular Weight:
351.76
Molecular Formula:
C14H10ClN3O4S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml)
Physical Properties:
Grey solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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