PluriSln#1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln#1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1 The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln#1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2 and chondrogenic cells3.
1) Ben-David et al. (2013), Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen; Cell Stem Cell. 12 167
2) Zhang et al. (2014), Inhibition of stearoyl-coA desaturase eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium; Cell Cycle 13 762
3) Cheng et al. (2014), Cartilage Repair Using Human Embryonic Stem Cell-Derived Chondroprogenitors; Stem Cells Transl. Med. 3 1287