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PluriSln#1 | Stearoyl CoA desaturase inhibitor

PluriSln#1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln#1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1 The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln#1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2 and chondrogenic cells3.

References/Citations
1) Ben-David et al. (2013), Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen; Cell Stem Cell. 12 167
2) Zhang et al. (2014), Inhibition of stearoyl-coA desaturase eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium; Cell Cycle 13 762
3) Cheng et al. (2014), Cartilage Repair Using Human Embryonic Stem Cell-Derived Chondroprogenitors; Stem Cells Transl. Med. 3 1287

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Focus Biomolecules supplier, chemical structure of PluriSln#1 | Stearoyl CoA desaturase inhibitor | CAS 91396-88-2

Catalog#  10-1451

$50.00
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CAS:
91396-88-2
Catalog Number:
10-1451
Activity:
Stearoyl CoA desaturase inhibitor
Alternate Names:
4-Pyridinecarboxylic acid 2-phenylhydrazide
Chemical Name:
N'-Phenylpyridine-4-carbohydrazide
Molecular Weight:
213.24
Molecular Formula:
C12H11N3O
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Beige solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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