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PP2 | Src family kinase inhibitor

PP2 (172889-27-9) is a potent and selective Src family kinase inhibitor. Inhibits Lck(IC50=4 nM); Fyn (IC50=5 nM); Hck (IC50=5 nM). It displays weak inhibition of EGFR (IC50=480 nM) and no inhibition of ZAP-70 (IC50> 100 μM) and JAK2 (IC50> 50 μM).1 PP2 is a useful probe for exploring the involvement of Src family kinases in signal transduction pathways.2

References/Citations
1) Hanke et al. (1996), Discovery of a novel, potent and Src family-selective kinase inhibitor. Study of Lck-and FynT-dependent T cell activation; J. Biol. Chem., 271 695
2) Yoshizume et al. (2000), Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species; J. Biol. Chem., 275 11706

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Focus Biomolecules supplier, chemical structure of PP2 | Src family kinase inhibitor | CAS 172889-27-9

Catalog#  10-1407

$60.00
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CAS:
172889-27-9
Catalog Number:
10-1407
Activity:
Src family kinase inhibitor
Chemical Name:
3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Molecular Weight:
301.78
Molecular Formula:
C15H16ClN5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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