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Product Details

PRE084 | Selective sigma-1 agonist

PRE084 (138847-85-8) is an agonist of the σ receptor with selectivity for the σ1 subtype (IC50’s: σ1 = 2.2nM, σ2 = 13091nM).1 PRE-084 has demonstrated neuroprotective/restorative effects in brain injury2,3 and neurodegenerative conditions4-7.

 

References/Citations

1) Su et al. (1991), Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand; J. Pharmacol. Exp. Ther. 259 543
2) Peviani et al. (2012), Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice; Exp. Neurol. 237 1388
3) Dong et al. (2016), Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury; Cell Mol. Neurobiol. 36 639
4) Guzman-Lenis et al. (2009), Selective sigma receptor agonist 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons; Neuroscience 162 31
5) Hyrskyluoto et al. (2013), Sigma-1 receptor agonist PRE084 in protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway; Cell Death Dis. 4 e646
6) Francardo et al. (2014), Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism; Brain 137(Pt7) 1998
7) Mancuso et al. (2012), Sigma-1R agonist improves motor function and motoneuron survival in ALS mice; Neurotherapeutics 9 814

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Catalog#  10-4203-0005

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
138847-85-5
Catalog Number:
10-4203
Activity:
Selective sigma-1 agonist
Chemical Name:
2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride
Molecular Weight:
353.89
Molecular Formula:
C19H27N)3 • HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 7 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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