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Prochlorperazine maleate | Endocytosis inhibitor

CAS:
84-02-6
Catalog Number:
10-3474
Activity:
Endocytosis inhibitor
Chemical Name:
2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate
Molecular Weight:
606.09
Molecular Formula:
C20H24ClN3S • 2C4H4O4
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 µM for CME.1 Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2 A clinically useful antipsychotic agent3 with antimigraine4 and antiemetic activity5.

References/Citations
1) Daniel et al. (2015), Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic, 16 635
2) Chew et al. (2020), Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell, 180 895
3) Hollister et al. (1969), Clinical use of psychotherapeutic drugs: current status; Clin. Pharmacol. Ther., 10 170
4) Cook and Newberry (2018), Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J., 40 148
5) Van den Berg et al. (1996), The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care, 24 538

Prochlorperazine maleate | Endocytosis inhibitor is also available in the Cellular Metabolism Library.
image
CAS:
84-02-6
Catalog Number:
10-3474
Activity:
Endocytosis inhibitor
Chemical Name:
2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate
Molecular Weight:
606.09
Molecular Formula:
C20H24ClN3S • 2C4H4O4
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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