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Prostaglandin A1 | Endogenous prostaglandin

Prostaglandin A1 (PGA1, 14152-28-4) is a naturally occurring prostaglandin with diverse biological actions including anti-hypertensive1,2, anti-inflammatory3,4, anti-viral5,6, and anticancer7,8.

References/Citations

1) Lee et al. (1972) Renal effects of prostaglandin A1 in patients with essential hypertension; Kidney Int. 1 254
2) Toppozada et al. (1988) Treatment of preeclampsia with prostaglandin A1; Am. J. Obstet. Gynecol. 159 160
3) Rossi et al. (2000) Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase; Nature 403 103
4) Mandal et al. (2005), Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation; J. Immunol. 175 6271
5) Carta et al. (2014) Prostaglandin A1 inhibits avian influenza virus replication at a postentry level: Effect on virus protein synthesis and NF-kB activity; Prostaglandins Leukot. Essential Fatty Acids 91 311
6) Tsukimoto et al. (2015) A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors; Antiviral Res. 117 1
7) Diez-Dacal et al. (2011) Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity; Cancer Res. 71 4161
8) Anta et al. (2016), PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes; Cell Death Dis. 7 e2311

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Catalog#  10-4461-0001

$30.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
14152-28-4
Catalog Number:
10-4461
Activity:
Endogenous prostaglandin
Chemical Name:
15(S)-9-Oxo-15-hydroxyprosta-10,13E-dien-1-oic acid
Alternate Names:
PGA1
Molecular Weight:
336.47
Molecular Formula:
C20H32O4
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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