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Product Details

Prostaglandin E1 | Vasodilator

PGE1 (745-65-3) is an endogenous prostaglandin with vasodilatory, anti-platelet, and, anti-hypertensive activities.1,2 It is in clinical use for the treatment of erectile dysfunction3 and the emergency management of infants with patent ductus arteriosus4. It has also been used in the treatment of peripheral arterial occlusive disease (PAD).5

References/Citations

1) Kirtland (1988) Prostaglandin E1: 1 review; Prostaglandins Leukot. Essent. Fatty Acids, 32 165
2) Schermuly et al. (2005) Prostanoids and Phosphodiesterase Inhibitors in Experimental Pulmonary Hypertension; Curr. Top. Dev. Biol. 67 251
3) Urciuoli et al (2004) Prostaglandin E1 for treatment of erectile dysfunction; Cochrane Database Syst. Rev. CD001784
4) Huang et al. (2013) Reappraisal of the prostaglandin E1 dose for early newborns with patent ductus arteriosus-dependent pulmonary circulation; Pediatr. Neonatol. 54 102
5) Schroer and Hohlfeld (2004) Mechanisms of anti-ischemic action of prostaglandin E1 in peripheral arterial occlusive disease; Vasa 33 119

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Catalog#  10-4455-0010

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
745-65-3
Catalog Number:
10-4455
Activity:
Vasodilator
Chemical Name:
(11a, 13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid
Alternate Names:
PGE1; Alprostadil
Molecular Weight:
354.49
Molecular Formula:
C20H34O5
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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