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Product Details

PSB-CB6 | GPR18 antagonist

PSB-CB5 (1627710-30-8) is a potent and selective GPR18 antagonist (IC50 = 0.279 μM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2.1  Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa.2

References/Citations

1) Rempel et al. (2014), Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55; Med. Chem. Comm., 5 632
2) Flegel et al. (2016), Characterization of Non-Olfactory GPCRs in Human Sperm With a Focus on GPR18; Sci. Rep., 6 32255

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Catalog#  10-5062-0005

$75.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1627710-30-8
Catalog Number:
10-5062
Activity:
GPR18 antagonist
Molecular Weight:
384.88
Molecular Formula:
C20H17ClN2O2S
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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