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Pseurotin A | Fungal metabolite with neuritogenic activity

CAS:
58523-30-1
Catalog Number:
10-2630
Activity:
Fungal metabolite with potent neuritogenic activity
Chemical Names:
Fermentation product of Aspergillus fumigatus
Molecular Weight:
431.44
Molecular Formula:
C22H25NO8
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Pseurotin A (58523-30-1) is a fungal metabolite with novel structure. Displays potent neuritogenic activity in PC12 cells. Induces multipolar and branching neurites comparable to that produced by β-NGF.1 Displays immunosuppressive activity via inhibition of immunoglobulin E production in vitro.2 Displays antiproliferative effects on four glioma cell lines by regulating tumor metabolic enzymes.3 Inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppression of ROS.4

References/Citations:

1) Komagata et al. (1996), Novel neuritogenic activities of pseurotin A and penicillic acid; J. Antibiot., 49 958
2) Ishikawa et al. (2009), Pseurotin A and its analogues as inhibitors of immunoglobulin E  production; Bioorg, Med. Chem. Lett., 19 1457
3) Anjum et al. (2018), Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes; Nat. Prod. Res., 32 1353
4) Chen et al. (2019), Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species; Theranostics, 9 1634

Pseurotin A | Fungal metabolite with neuritogenic activity is also available in the Cellular Metabolism Library.
CAS:
58523-30-1
Catalog Number:
10-2630
Activity:
Fungal metabolite with potent neuritogenic activity
Chemical Names:
Fermentation product of Aspergillus fumigatus
Molecular Weight:
431.44
Molecular Formula:
C22H25NO8
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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