Pterostilbene (537-42-8) is a naturally occurring stilbenoid related to resveratrol (Cat.# 10-1057). Displays antiproliferative activity. Induces accumulation of autophagic vacuoles followed by cell death in HL60 cells1. Pterostilbene displays protective effects against free radical-mediated oxidative damage2. Produces anti-inflammatory effects by down-regulating the activity of TNFα3. Activates AMPK4.
1) Siedlecka-Kroplewska et al. (2013), Pterostilbene induces accumulation of autophagic vacuoles followed by cell death in HL60 human leukemia cells; J. Physiol. Phamracol., 64 545
2) Acharya et al. (2013), Protective effect of Pterostilbene against free radical mediated oxidative damage; BMC Complernt Altern. Med., 13 238
3) McCormack et al. (2012), Pterostilbene ameliorates tumor necrosis factor alpha-induced pancreatitis in vitro; Infect. J. Surg. Res., 178 28
4) Lin et al. (2012), Activation of AMPK by pterostilbene suppresses lipogensis and cell-cycle progression in p53 positive and negative human prostate cancer cells; J. Agric. Food Chem., 60 6399