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Product Details

PUGNAc | O-GlcNAcase inhibitor

PUGNAc (CAS 132489-69-1) is an O-GlcNAcase (O-GlcNAc-β-N-acetylglucosaminidase) and β-hexosaminidase inhibitor (Ki=46 and 36 nM, respectively). A widely used tool for increasing cellular levels of O-GlcNAc.2 Protects cardiac function after trauma-hemorrhage which is mediated by increased protein O-GlcNAc levels.3 Induces insulin resistance in rat skeletal muscle.4

References/Citations

1) Macauley et al. (2005), O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors; J. Biol. Chem., 280 25313
2) Kneass and Marchase (2005), Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils; J. Biol. Chem., 280 14579
3) Zou et al. (2007), The protective effects of PUGNAC on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels; Shock, 27 402
4) Arias et al. (2004), Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle; Diabetes, 53 921

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Focus Biomolecules cell signaling reagent supplier, chemical structure of PUGNAc | O-GlcNAcase inhibitor | CAS 132489-69-1

Catalog#  10-2406-0005

$112.00
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CAS:
132489-69-1
Catalog Number:
10-2406
Activity:
O-GlcNAcase inhibitor
Chemical Name:
O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
Molecular Weight:
353.33
Molecular Formula:
C15H19N3O7
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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