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Product Details

Punicalagin | Anti inflammatory

Punicalagin (65995-63-3) is a polyphenolic compound isolated from pomegranates possessing antioxidant, anti-inflammatory, and antitumorigenic properties.1,2 It has been shown to reduce high glucose-induced neural tube defects by blocking cellular stress and caspase activation.3 Punicalagin prevented high-fat diet induced obesity associated accumulation of cardiac triglyceride and cholesterol as well as myocardial damage via AMPK mediated modulation of mitochondria and phase II enzymes.4

1) Seeram et al. (2005), In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice; J. Nutr. Biochem., 16 360
2) Adams et al. (2006), Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells; J. Agric. Food Chem., 54 980
3) Zhong et al. (2015), Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects; Biochem. Biophys. Res. Commun., 467 179
4) Cao et al. (2015), Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation; Sci. Rep., 5 14014

Focus Biomolecules cell signaling reagent supplier, chemical structure of Punicalagin | Anti inflammatory | CAS 65995-63-3

Catalog#  10-4583

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Catalog Number:
Anti-inflammatory / antioxidant / anti-tumor agent
Molecular Weight:
Molecular Formula:
Soluble in Water (greater than 20 mg/ml)
Physical Properties:
Yellow solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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