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Product Details

PX-866 | PI3-K inhibitor

PX-866 (502632-66-8) inhibits PI-3 Kinase with selectivity for p110α (IC50=0.1 nM). Counteracts hypoxia-related downregulation of E7 expression in HPV-positive cancer cells.2 Displays antitumor activity. Irreversible. Cell permeable.

References/Citations
1) Ihle et al. (2004), Molecular pharmacology and antitumor activity of PK-866, a novel inhibitor of phosphoinositide-3-kinase signaling; Mol. Cancer Ther., 3 763
2) Bossler et al. (2019) Repression of Human Papilloma Virus Oncogene Expression Under Hypoxia is Mediated by PI3K/mTORC2/AKT Signaling; mBio, 10 e02323 [Focus Citation]

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Focus Biomolecules cell signaling reagent supplier, chemical structure of PX-866 | PI3-K inhibitor | CAS 502632-66-8

Catalog#  10-1315

$58.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
502632-66-8
Catalog Number:
10-1315
Activity:
PI3-K inhibitor
Molecular Weight:
525.6
Molecular Formula:
C29H35NO8
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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