Pyr3 (1160514-60-2) is a selective antagonist of the TRP canonical 3 channel (TRPC3)1 which can function as a receptor-operated channel2. A useful tool for dissecting GPCR-downstream signaling mechanisms3. Pyr3 may be effective in reducing cardiac hypertrophy2.
1) Kiyonaka et al. (2009), Selective and direct inhibition of TRPC3 channels inderlies biological activities of a pyrazole compound; Proc. Natl. Acad. Sci. USA., 106 5400
2) Eder and Molkentin (2011), TRPC channels as effectors of cardiac hypertrophy; Circ. Res., 108 265
3) Sabourin et al. (2012), Activation of transient receptors potential canonical 3 (TRPC3)-mediated CA2+ entry by A1 adenosine receptor in cardiomyocytes disturbs atrioventricular conduction; J. Biol. Chem., 287 26688