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Product Details

Q-VD-OPh | Pan-specific caspase inhibitor

Q-VD-OPh (1135695-98-5) is a potent and highly effective pan-caspase inhibitor with potent antiapoptotic activity which is not toxic to cells.1 Displays protective effects on brain damage and bacterial infection in a murine MCAO stroke model.2 Switches doxorubicin-induced apoptosis to an alternative default cell death mode marked by increased expression of senescence markers.3 Blocks staurosporin-induced differentiation of embryonic stem cells to cardiomyocytes.4 Trophoblasts treated with ceramide and Q-VD-OPh undergo necroptosis.5

References/Citations

1) Caserta et al. (2003), Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties; Apoptosis, 8 345
2) Braun et al. (2007), Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH; Exp. Neurol., 206 183
3) Rebbaa et al. (2003), Caspase inhibition switches doxorubicin-induced apoptosis to senescence; Oncogene, 22 2805
4) Bulatovic et al. (2015), Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells; PLoS One, 10 e0120176
5) Bailey et al. (2017), Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis; Cell Death Dis., 8 e2590

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Focus Biomolecules cell signaling supplier, chemical structure Q-VD-OPh | Pan-specific caspase inhibitor | CAS 1135695-98-5

Catalog#  10-2940-0001

$100.00
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CAS:
1135695-98-5
Catalog Number:
10-2940
Activity:
Pan-specific caspase inhibitor
Chemical Name:
Quinolyl-valyl-aspartyl-[2,6-difluorophenoxy]methyl ketone
Molecular Weight:
513.49
Molecular Formula:
C26H25F2N3O6
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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