Quetiapine hemifumarate | Atypical antipsychotic agent
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 50 mg | $30.00 | ||
| 500 mg | $50.00 |
Quetiapine hemifumarate (111974-72-2) is an atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively.2 Reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation in a rat model.3 Efficacious as a monotherapy in the treatment of posttraumatic stress disorder.4 Quetiapine promotes oligodendroglial differentiation and remyelination via upregulation of oligodendrocyte transcription factor 1 (Olig1).5 Promotes myelin repair by inhibiting microglial activation.6
References/Citations
1) Ellenbroek et al. (1996); Activity of “seroquel” (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with clozapine; Neuropsychopharmacology 15 406
2) Saller and Salama (1993), Seroquel: biochemical profile of a potential atypical antipsychotic; Psychopharmacology (Berl) 112 285
3) Ignacio et al. (2017), Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation; Behav. Brain Res. 320 225
4) Villarreal et al. (2016), Efficacy of Quetiapine Monotherapy in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial; Am. J. Psychiatry 173 1205
5) Wang et al. (2021), Quetiapine promotes oligodendroglial process outgrowth and membrane expansion by orchestrating the effects of Olig1; Glia 69 1709
6) Wang et al. (2015), Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination; Front. Cell. Neurosci. 9 492
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Quetiapine hemifumarate (111974-72-2) is an atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively.2 Reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation in a rat model.3 Efficacious as a monotherapy in the treatment of posttraumatic stress disorder.4 Quetiapine promotes oligodendroglial differentiation and remyelination via upregulation of oligodendrocyte transcription factor 1 (Olig1).5 Promotes myelin repair by inhibiting microglial activation.6
References/Citations
1) Ellenbroek et al. (1996); Activity of “seroquel” (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with clozapine; Neuropsychopharmacology 15 406
2) Saller and Salama (1993), Seroquel: biochemical profile of a potential atypical antipsychotic; Psychopharmacology (Berl) 112 285
3) Ignacio et al. (2017), Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation; Behav. Brain Res. 320 225
4) Villarreal et al. (2016), Efficacy of Quetiapine Monotherapy in Posttraumatic Stress Disorder: A Randomized, Placebo-Controlled Trial; Am. J. Psychiatry 173 1205
5) Wang et al. (2021), Quetiapine promotes oligodendroglial process outgrowth and membrane expansion by orchestrating the effects of Olig1; Glia 69 1709
6) Wang et al. (2015), Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1-Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repair in a Cuprizone-Induced Mouse Model of Demyelination; Front. Cell. Neurosci. 9 492
Related products
-
Phenylbutyrate Na | HDAC inhibitor
From $35.00CAS:1716-12-7Catalog Number:10-1118Activity:HDAC inhibitorAlternate Names:4-PB, PBNaChemical Name:4-Phenylbutyric acid sodium saltMolecular Weight:186.18Molecular Formula:C10H11NaO2Solubility:Soluble in DMSO (up to 4 mg/ml) or in Water (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT -
FK-506 | FKBP inhibitor
From $50.00CAS:104987-11-3Catalog Number:10-1103Activity:FKBP inhibitorAlternate Names:TacrolimusMolecular Weight:804.04Molecular Formula:C44H69NO12Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
Zileuton | 5-LO inhibitor
From $32.00CAS:111406-87-2Catalog Number:10-1098Activity:5-LO inhibitorChemical Name:N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyureaMolecular Weight:236.29Molecular Formula:C11H12N2O2SSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:>98%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
