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Product Details

Quinacrine HCl | Antiprotozoan / Anticancer

Quinacrine HCl (69-05-6) is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been found to have synergistic effects with vorinostat in the treatment of T-cell acute lymphoblastic leukemia via mitophagy blockage and an increase in ROS.2 Quinacrine displayed antitumor effects in an intestinal cancer mouse model and HCT116 p53-/- xenografts via reduction in Chk1/2 expression and cell death induction in the G2-M phase.3 It promotes autophagic cell death in ovarian cancer cells via downregulation of p62/SQSTM1.4 Quinacrine is also an inhibitor of phospholipase A2.5

References/Citations

1) Ehsanian et al. (2011), Beyond DNA binding – a review of the potential mechanisms mediating quinacrine’s therapeutic activities in parasitic infections, inflammation, and cancers; Cell Commun. Signal. 9 13
2) Jing et al. (2018), Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition; Cell Death Disease 9 589
3) Park et al. (2018), Therapeutic Effect of Quinacrine, an Antiprotozoan Drug, by Selective Suppression of p-CHK1/2 in p53-Negative Malignant Cancers; Mol. Cancer Res. 16 935
4) Khurana et al. (2015), Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth; Oncotarget 6 36354
5) Chan et al. (1982), Biphasic modulation of platelet phospholipase A2 activity and platelet aggregation by mepacrine (quinacrine); Biochim. Biophys. Acta 713 170

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Catalog#  10-4251-0020

$30.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
69-05-9
Catalog Number:
10-4251
Activity:
Antiprotozoan / Anticancer
Chemical Name:
6-Chloro-9-(4-diethylamino-1-methylbutyl)amino-2-methoxyacridine dihydrochloride
Molecular Weight:
472.88
Molecular Formula:
C23H30ClN3O • 2HCl
Solubility:
Soluble in Water (up to at least 25 mg/ml) or in DMSO (up to at least 10 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. Solutions in water should be made fresh daily.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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