(R)-PFI-2 HCl | Methyltransferase SETD7 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $270.00 |
(R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7.1 It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a SETD7-dependent manner.
References/Citations:
1) Barsyte-Lovejoy et al. (2014), (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells; Proc. Natl. Acad. Sci. USA 111 12853
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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(R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7.1 It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a SETD7-dependent manner.
References/Citations:
1) Barsyte-Lovejoy et al. (2014), (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells; Proc. Natl. Acad. Sci. USA 111 12853
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