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Radicicol | HSP90 inhibitor

Radicicol (12772-57-5) inhibits heat shock protein 90 (HSP90) activity by binding to the ATP-binding pocket.1 In cells HSP90 client proteins such as Raf kinase2, HIF-1α3 and estrogen receptor4 are destabilized and proteolytically degraded. Radicicol inhibits expression of COX-2 without affecting COX-1 expression in LPS-stimulated macrophages (IC50=27 nM).5 Inhibits angiogenesis.6


1) Schulte et al. (1999), Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones; Mol. Endocrinol., 13 1435
2) Soga et al. (1998), Radicicol leads to selective depletion of Raf kinase and disrupts K-Ras-activated aberrant signaling pathway; J. Biol. Chem., 273 822
3) Hur et al. (2002) Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol; Mol. Pharmacol., 62 975
4) Lee et al. (2002) Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90; Mol. Cell. Endocrinol., 188 47
5) Chanmugam et al. (1995) Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis; J. Biol. Chem., 270 5418
6) Oikawa et al. (1993) Radicicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis; Eur. J. Pharmacol., 241 221

Focus Biomolecules cell signaling reagent supplier, chemical structure of Radicicol | HSP90 inhibitor | CAS 12772-57-5

Catalog#  10-2102-0001

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Catalog Number:
HSP90 inhibitor
Chemical Name:
Alternate Names:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 8 mg/ml).
Physical Properties:
White solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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