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Rbin-1 | Eukaryotic ribosome assembly inhibitor

Rbin-1 (328023-11-6) is potent (GI50 = 136 nM) and reversible inhibitor of eukaryotic ribosome assembly.  The biochemical target of Rbin-1 is Midasin (Mdn1), an essential AAA+ protein.  Blocking of Mdn1 by Rbin-1 inhibits the processing of pre-60S particles, important pre-ribosomal subunits produced in the nucleolus.

References/Citations

1) Kawashime et al. (2016), Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell 167 512

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Focus Biomolecules supplier, chemical structure of Rbin-1 | Eukaryotic ribosome assembly inhibitor | CAS 328023-11-6

Catalog#  10-4606

$50.00
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CAS:
328023-11-6
Catalog Number:
10-4606
Activity:
Eukaryotic ribosome assembly inhibitor
Chemical Name:
3-[(2-Methyl-2-propen-1-yl)sulfanyl]-5H-[1,2,4]triazino[5,6-b]indole
Molecular Weight:
256.33
Molecular Formula:
C13H12N4S
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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