CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), originally found in prokaryotic genomes, is paired with Cas endonucleases to effect nucleotide insertions and deletions, enabling many applications that include DNA/RNA editing and diagnostics. Many related techniques continue to be developed and improved upon. Several small molecules reagents are available that enhance the overall efficiency and targeting precision of CRISPR/Cas9-mediated editing.
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