RAF
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Dabrafenib | B-Raf mutant inhibitor
From $40.00CAS:1195765-45-7Catalog Number:10-1569Activity:B-Raf mutant inhibitorChemical Name:N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamideAlternate Names:GSK2118436Molecular Weight:519.56Molecular Formula:C23H20F3N5O2SSolubility:Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).Physical Properties:Off-white solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
GW-5074 | c-Raf1 inhibitor
From $60.00CAS:220904-83-6Catalog Number:10-1031Activity:c-Raf1 inhibitorChemical Name:3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-oneMolecular Weight:520.95Molecular Formula:C15H8Br2INO2Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Dark orange solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT -
Locostatin | RKIP/Raf-1 kinase disruptor
From $48.00CAS:133812-16-5Catalog Number:10-5381Activity:RKIP/Raf-1 kinase disruptorChemical Names:(4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone; UIC-1005Molecular Weight:245.28Molecular Formula:C14H15O3Solubility:Soluble in DMSO (60 mg/ml)Physical Properties:Off-white solidPurity:>98% TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
PLX-4032 | BRAF inhibitor
From $40.00CAS:918504-65-1Catalog Number:10-2928Activity:BRAF inhibitorChemical Name:N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamideAlternate Names:Vemurafenib, R7204, Ro 51-85426Molecular Weight:489.92Molecular Formula:C23H18ClF2N3O3SSolubility:Soluble in DMSO (up to 100 mg/ml)Physical Properties:White or off-white solidPurity:99% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
PLX4720 | Mutant B-Raf inhibitor
From $55.00CAS:918505-84-7Catalog Number:10-5113Activity:Mutant B-Raf inhibitorChemical Names:N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamideMolecular Weight:413.82Molecular Formula:C17H14ClF2N3O3SSolubility:Soluble in DMSO (30 mg/ml with warming)Physical Properties:White solidPurity:>98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT
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