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Product Details

Remodelin | Acetyl-transferase NAT10 inhibitor

Remodelin (949912-58-7) is a potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones.1 Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells1, normalizing progeric and aging cells2. Enhances health span in a mouse model of human accelerated aging syndrome.3 Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A.4 Inhibits NAT10-promoted metastasis which may be mediated  by endothelial-to-mesenchymal transition in hepatocellular carcinoma.5

1) Larrieu et al. (2014), Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells; Science, 344 527
2) Larrieu et al. (2018), Inhibition of the Acetyltransferase NAT10 Normalizaes Progeric and Aging Cells by Rebalancing the Transportin-1 Nuclear Import Pathway; Sci. Signal., 11
3) Balmus et al. (2018), Targeting of NAT10 Enhances Healthspan in a Mouse Model of Human Accelerated Aging Syndrome; Nature Commun., 9 1700
4) Cobb et al. (2016), Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient; Aging Cell, 15 1039
5) Ma et al. (2016), Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition; Am. J. Transl. Res., 8 4215

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Catalog#  10-5085-0005

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Catalog Number:
Acetyl-transferase NAT10 inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
Pale yellow solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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