Reserpine | VMAT1,2 inhibitor
NMR (Conforms)
Reserpine (50-55-5) is an indole alkaloid isolated from Rauwolfia serpentina which acts as a potent antihypertensive agent. Irreversibly inhibits both isoforms of vesicular monoamine transporter VMAT1 and 2, Ki=34 and 12 nM, respectively.1,2 May be used to pharmacologically deplete monoamines in various animal models.3 Inhibits the multidrug resistance protein P-glycoprotein, IC50=0.5 mM.3 Reserpine-induced hypokinesia is considered a useful animal model of Parkinson’s disease.5
References:
- Schuldiner et al. (1993), Reserpine binding to vesicular amine transporter expressed in Chinese hamster ovary fibroblasts; J. Biol. Chem., 268 29
- Erickson et al. (1996), Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter; Proc. Natl. Acad. Sci. USA, 93 5166
- Antkiewicz et al. (2014), Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat; Neurotox. Res., 26 85
- Wang et al. (2001), Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4; Res. Toxicol., 14 1596
- Duty et al. (2011), Animal models of Parkinson’s disease: a source of novel treatments and clues to the cause of the disease; Oncotarget, 164 1357
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Reserpine (50-55-5) is an indole alkaloid isolated from Rauwolfia serpentina which acts as a potent antihypertensive agent. Irreversibly inhibits both isoforms of vesicular monoamine transporter VMAT1 and 2, Ki=34 and 12 nM, respectively.1,2 May be used to pharmacologically deplete monoamines in various animal models.3 Inhibits the multidrug resistance protein P-glycoprotein, IC50=0.5 mM.3 Reserpine-induced hypokinesia is considered a useful animal model of Parkinson’s disease.5
References:
- Schuldiner et al. (1993), Reserpine binding to vesicular amine transporter expressed in Chinese hamster ovary fibroblasts; J. Biol. Chem., 268 29
- Erickson et al. (1996), Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter; Proc. Natl. Acad. Sci. USA, 93 5166
- Antkiewicz et al. (2014), Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat; Neurotox. Res., 26 85
- Wang et al. (2001), Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4; Res. Toxicol., 14 1596
- Duty et al. (2011), Animal models of Parkinson’s disease: a source of novel treatments and clues to the cause of the disease; Oncotarget, 164 1357
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