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RG-108 | DNA Methyltransferase inhibitor

RG-108 (48208-26-0) is a non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. RG-108 enhances the reversion of neural progenitor cells to the pluripotent state3.

References/Citations
1) Brueckner et al. (2005), Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferase; Cancer Res., 65 6305
2) Stresemann et al. (2006), Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines; Cancer Res., 66 2794
3) Szablowska-Gadomska et al. (2012), Treatment with small molecules is an important milestone towards the induction of pluripotency in neural stem cells derived from human cord blood; Acta Neurobiol. Exp., 72 337

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Focus Biomolecules supplier, chemical structure of RG-108 | DNA Methyltransferase inhibitor | CAS 48208-26-0

Catalog#  10-2546

$40.00
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CAS:
48208-26-0
Catalog Number:
10-2546
Activity:
DNA Methyltransferase inhibitor
Alternate Names:
N-Phthalyl-L-tryptophan
Chemical Name:
(S)-2-(1,3-Dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
Molecular Weight:
334.34
Molecular Formula:
C19H14N2O4
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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