RGFP966 | Selective HDAC3 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $270.00 |
RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited @ 15µM).1 It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5
References/Citations:
1) Malvaez et al. (2013), HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA 110 2647
2) Bieszczad et al. (2015), Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci. 35 13124
3) Zhu et al. (2017), HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease; Aging Cell 16 1073
4) Haiqun et al. (2016), The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498
5) Janczura et al. (2018), Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA 115 E11148
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited @ 15µM).1 It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5
References/Citations:
1) Malvaez et al. (2013), HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA 110 2647
2) Bieszczad et al. (2015), Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci. 35 13124
3) Zhu et al. (2017), HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease; Aging Cell 16 1073
4) Haiqun et al. (2016), The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498
5) Janczura et al. (2018), Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA 115 E11148
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