RGN6024 | Tubulin destabilizer

CAS:
 3055038-20-2
Catalog Number:
 10-4227
RGN6024 chemical structure

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RGN6024 (3055038-20-2) is an orally bioavailable and brain-penetrant tubulin destabilizer. It inhibits microtubule polymerization by binding to the colchicine binding site of ß-tubulin. Active in glioblastoma cell lines with nanomolar potency. RGN6024 was active in vivo in temozolomide-resistant LN-18 and BT142 glioblastoma xenograft models

References/Citations:

  1. Patron et al. (2025), RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment for Glioblastoma; Mol. Cancer Ther. 24 1129
3055038-20-2, RGN-6024, RGN6024, RGN6024 supplier, tubulin destabilizer
CAS:
3055038-20-2
Catalog Number:
10-4227
Activity:
Tubulin destabilizer
Chemical Names:
3-Methoxy-N-(5-((2-morpholinopyrimidin-5-yl)oxy)thiazol-2-yl)bicyclo[1.1.1]pentane-1-carboxamide
Molecular Weight:
403.46
Molecular Formula:

C18H21N5O4S

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to pale orange solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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Product Data Sheet:

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RGN6024 (3055038-20-2) is an orally bioavailable and brain-penetrant tubulin destabilizer. It inhibits microtubule polymerization by binding to the colchicine binding site of ß-tubulin. Active in glioblastoma cell lines with nanomolar potency. RGN6024 was active in vivo in temozolomide-resistant LN-18 and BT142 glioblastoma xenograft models

References/Citations:

  1. Patron et al. (2025), RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment for Glioblastoma; Mol. Cancer Ther. 24 1129

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