RIPA-56 | RIP1 kinase inhibitor

CAS:
1956370-21-0
Catalog Number:
10-4611
Activity:
RIP1 kinase inhibitor
Chemical Name:
N-Benzyl-N-hydroxy-2,2-dimethylbutanamide
Molecular Weight:
221.30
Molecular Formula:
C13H19NO2
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$55.00
50 mg$170.00

RIPA-56 (1956370-21-0) is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver microsomal stability assay).  RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM. It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2

References/Citations:

1) Ren et al. (2017), Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J. Med. Chem. 60 972

2) Zhang et al. (2019), RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation; Proc.Natl.Acad.Sci.USA 116 5675

CAS:
1956370-21-0
Catalog Number:
10-4611
Activity:
RIP1 kinase inhibitor
Chemical Name:
N-Benzyl-N-hydroxy-2,2-dimethylbutanamide
Molecular Weight:
221.30
Molecular Formula:
C13H19NO2
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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