Size : | Price | Quantity | |
---|---|---|---|
10 mg | $55.00 | ||
50 mg | $170.00 |
RIPA-56 (1956370-21-0) is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM. It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2
References/Citations:
1) Ren et al. (2017), Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J. Med. Chem. 60 972
2) Zhang et al. (2019), RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation; Proc.Natl.Acad.Sci.USA 116 5675
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RIPA-56 (1956370-21-0) is a potent (IC50 = 13 nM, EC50 = 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2 = 128min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM. It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2
References/Citations:
1) Ren et al. (2017), Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J. Med. Chem. 60 972
2) Zhang et al. (2019), RIP1 kinase inhibitor halts the progression of an immune-induced demyelination disease at the stage of monocyte elevation; Proc.Natl.Acad.Sci.USA 116 5675
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