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Product Details

Ro 41-5253 | RARa antagonist

Ro 415253 (144092-31-9) is a selective RARα antagonist.1 Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2 Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.

References/Citations
1) Apfel et al. (1992), A retinoic acid receptor _ antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA, 89 7129
2) Toma et al. (1998), RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer, 78 86

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Ro 41-5253 | RARa antagonist | CAS 144092-31-9

Catalog#  10-4504

$75.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
144092-31-9
Catalog Number:
10-4504
Activity:
RARα antagonist
Molecular Weight:
484.65
Molecular Formula:
C28H36O5S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 12 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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