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Rofecoxib | Selective COX-2 inhibitor

Rofecoxib (162011-90-7) is a potent and selective COX-2 inhibitor with 1000-fold selectivity over COX-1, IC50=26 nm vs >50 μM1. Potent nonsteroidal anti-inflammatory agent1. Rofecoxib is a clinically useful NSAID which was withdrawn from use due to cardiovascular side effects3.

References/Citations
1) Chan et al. (1999), Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles; J. Pharmacol. Exp. Ther., 290 551
2) Catalla-Lawson et al. (2013), Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamnics and vasoactive eicosanoids; J. Pharmacol. Exp. Ther., 289 735

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Focus Biomolecules cell signaling tech supplier, chemical structure Rofecoxib | Selective COX-2 inhibitor | CAS 162011-90-7

Catalog#  10-2440

$60.00
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CAS:
162011-90-7
Catalog Number:
10-2440
Activity:
Selective COX-2 inhibitor
Alternate Names:
MK-966
Chemical Name:
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Molecular Weight:
314.36
Molecular Formula:
C17H14O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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