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Product Details

Rolipram | PDE4 inhibitor

Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.

References/Citations
1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase; Biochem. J., 241 535
2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum; J. Neurosci., 28 10460
3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Rolipram | PDE4 inhibitor | CAS 61413-54-5

Catalog#  10-1079

$60.00
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CAS:
61413-54-5
Catalog Number:
10-1079
Activity:
PDE4 inhibitor
Alternate Names:
ZK 62711
Chemical Name:
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (racemic)
Molecular Weight:
275.35
Molecular Formula:
C16H21NO3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR conforms
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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