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Product Details

Rottlerin | PKCdelta inhibitor

Rottlerin (82-08-6) has been reported to inhibit PKCδ selectively however this result has been called into question.1 Displays neuroprotective effects.2 Induces autophagy.3 Cell permeable.

References/Citations
1) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95
2) Zhang et al. (2007), Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease; J. Pharmacol. Exp. Ther., 322 913
3) Balgi et al. (2009), Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling; PLoS One, 4 e7124

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Rottlerin | PKCdelta inhibitor | CAS 82-08-6

Catalog#  10-1341

$50.00
Quantity
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CAS:
82-08-6
Catalog Number:
10-1341
Activity:
PKCδ inhibitor
Chemical Name:
3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone
Molecular Weight:
516.65
Molecular Formula:
C30H28O8
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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