RPI-GLYT2-82 | GLYT2 antagonist

CAS:
 N/A
Catalog Number:
 10-4279
RPI-GLYT2-82 chemical structure

Available Options

Size:PriceQuantity 
5 mg$85.00
25 mg$315.00
Request Quote / Bulk / Custom Size
Product Inquiry

RPI-GLYT2-82 is a reversible, allosteric antagonist (IC50 = 554 nM) of Glycine Transporter 2(GLYT2) with selectivity over GLYT1. It is also an antagonist of the serotonin receptor 5-HT2A (IC50 = 1.9 µM). RPI-GLYT2-82 displayed efficacy in the CCI and PSNL mouse models of neuropathic pain.  It showed no addiction liability and had no on-target side effects.

References/Citations:

  1. Chater et al. (2026), A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects; Nat. Commun. 17 2828
  2. Cioffi et al. (2026), Identification of Non-competitive and Reversible Inhibitors of Glycine Transporter 2: A Promising Non-opioid Therapeutic Strategy for Neuropathic Pain; J. Med. Chem. 69 10278
GLYT2 antagonist, GLYT2 inhibitor, RPI-GLYT2-82, RPI-GLYT2-82 supplier
CAS:
N/A
Catalog Number:
10-4279
Activity:
GLYT2 antagonist
Chemical Names:
1-Benzoyl-N-((4-(dimethyamino)tetrahydro-2H-pyran-4-yl)methyl)indoline-5-carboxamide hydrochloride
Molecular Weight:
443.97
Molecular Formula:

C24H29N3O3·HCl

Solubility:
Soluble in DMSO (> 100 mg/ml)
Physical Properties:
Off-white to beige solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

RPI-GLYT2-82 is a reversible, allosteric antagonist (IC50 = 554 nM) of Glycine Transporter 2(GLYT2) with selectivity over GLYT1. It is also an antagonist of the serotonin receptor 5-HT2A (IC50 = 1.9 µM). RPI-GLYT2-82 displayed efficacy in the CCI and PSNL mouse models of neuropathic pain.  It showed no addiction liability and had no on-target side effects.

References/Citations:

  1. Chater et al. (2026), A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects; Nat. Commun. 17 2828
  2. Cioffi et al. (2026), Identification of Non-competitive and Reversible Inhibitors of Glycine Transporter 2: A Promising Non-opioid Therapeutic Strategy for Neuropathic Pain; J. Med. Chem. 69 10278

STEM CELL

BOGO