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Product Details

RS-1 | RAD51 activator / CRISPR enhancer

RAD51 (CAS 312756-74-2) is a strand exchange protein that is critical for the central steps in homologous recombination (HR) of DNA during double strand break repair. Because HR usually occurs without mutations, it is critically important for maintaining genomic stability. RS-1 is a small molecule that enhances the HR activity of RAD51 by promoting the formation of active presynaptic filaments during repair.1 At low micromolar levels, it was able to increase cellular resistance of neonatal human dermal fibroblasts to the chemotherapeutic agent cisplatin. HR stimulation in various cell types could lead to temporary protection from DNA damaging agents. RS-1 has been used to exploit the RAD51 overexpression in cancerous cells by inducing lethality via genotoxic RAD51 protein complexes.2 RS-1 has also been found to be a potent enhancer of CRISPR- and TALEN- based gene editing.3,4


1) Jayathilaka et al. (2008), A chemical compound that stimulates the human homologous recombination protein RAD51; Proc. Natl. Acad. Sci. USA 105 15848
2) Mason et al. (2014), The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors; Cancer Res. 74 3546
3) Pinder et al. (2015), Nuclear domain ‘knock-in’ screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing; Nucleic Acids Res. 43 9379
4) Song et al. (2016), RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency; Nat. Commun. 7 10548

Focus Biomolecules cell signaling supplier, chemical structure of RS-1 | RAD51 activator | CRISPR enhancer | CAS 312756-74-4

Catalog#  10-4099-0010

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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Catalog Number:
RAD51 activators / CRISPR enhancer
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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