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Product Details

RVX-208 | BET bromodomain inhibitor

RVX-208 (1044870-39-4) is a potent BET bromodomain antagonist with IC50 of 0.510 μM for BD2, with approximately 170-fold selectivity over BD11,2. RVX-208 increases apolipoprotein A-1 and HDL cholesterol in vitro and in vivo3. Reduces atherosclerosis4.

References/Citations
1) Picaud et al. (2013), RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain; Proc. Natl. Acad. Sci. USA, 110 19754
2) McLure et al. (2013), RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist; PLoS One, 8 e83190
3) Bailey et al. (2010), RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo; J. Am. Coll. Cardiol., 55 2580
4) Jahagirdar et al. (2014), A novel BET bromodomain inhibitor, RVX-208 shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice; Atherosclerosis, 236 91

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RVX-208 | 1044870-39-4 | Structure | Supplier

Catalog#  10-1487

$68.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1044870-39-4
Catalog Number:
10-1487
Activity:
BET bromodomain inhibitor
Chemical Name:
2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-4(3H)-quinzolinone
Molecular Weight:
370.41
Molecular Formula:
C20H22N2O5
Solubility:
Soluble in DMSO (up to 75 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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