Helicase inhibitor (S)-27 | WRN helicase inhibitor

CAS:
 3058652-58-4
Catalog Number:
 10-3966
(S)-27 chemical structure

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(S)-27 (3058652-58-4) is a potent (pIC50(0 hr/4hr) = 5.4/7.5) inhibitor of WRN helicase. Inhibition is via covalent binding to WRN Cys727.  (S)-27 inhibited (pIC50 = 5.0) the high microsatellite instability colon adenocarcinoma line SW48 (MSI-H).

References/Citations:

  1. Rowe et al. (2025) ‘Direct-to-biology’ drives optimization of a cell-active covalent inhibitor of WRN helicase; ChemRxiv March 6
(S)-27, (S)-27 supplier, (S)-27 WRn helicase, 3058652-58-4, helicase inhibitor, Helicase inhibitor (S)-27, WRN-helicase inhibitor
CAS:
3058652-58-4
Catalog Number:
10-3966
Activity:
WRN helicase inhibitor
Chemical Names:
(S)-1-(2-(2-Azaspiro[3.3]heptane-2-carbonyl)-4-(2-(4-(trifluoromethyl)phenyl)acetyl)piperazin-1-yl)prop-2-en-1-one
Molecular Weight:
449.47
Molecular Formula:

C23H26F3N3O3

Solubility:
Soluble in DMSO (>100 mg/ml)
Physical Properties:
Off-white to white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 months.
Shipping Code:
RT

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(S)-27 (3058652-58-4) is a potent (pIC50(0 hr/4hr) = 5.4/7.5) inhibitor of WRN helicase. Inhibition is via covalent binding to WRN Cys727.  (S)-27 inhibited (pIC50 = 5.0) the high microsatellite instability colon adenocarcinoma line SW48 (MSI-H).

References/Citations:

  1. Rowe et al. (2025) ‘Direct-to-biology’ drives optimization of a cell-active covalent inhibitor of WRN helicase; ChemRxiv March 6

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