Helicase inhibitor (S)-27 | WRN helicase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $300.00 |
(S)-27 (3058652-58-4) is a potent (pIC50(0 hr/4hr) = 5.4/7.5) inhibitor of WRN helicase. Inhibition is via covalent binding to WRN Cys727. (S)-27 inhibited (pIC50 = 5.0) the high microsatellite instability colon adenocarcinoma line SW48 (MSI-H).
References/Citations:
- Rowe et al. (2025) ‘Direct-to-biology’ drives optimization of a cell-active covalent inhibitor of WRN helicase; ChemRxiv March 6
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
(S)-27 (3058652-58-4) is a potent (pIC50(0 hr/4hr) = 5.4/7.5) inhibitor of WRN helicase. Inhibition is via covalent binding to WRN Cys727. (S)-27 inhibited (pIC50 = 5.0) the high microsatellite instability colon adenocarcinoma line SW48 (MSI-H).
References/Citations:
- Rowe et al. (2025) ‘Direct-to-biology’ drives optimization of a cell-active covalent inhibitor of WRN helicase; ChemRxiv March 6
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