(S)-Equol | Phytoestrogen

CAS:
 531-95-3
Catalog Number:
 10-3718
(S)-Equol chemical structure

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(S)-Equol (531-95-3) is a phytoestrogen produced via metabolic transformation of the isoflavonoid daidzein by human intestinal microflora.1 The estrogen receptor (ER) binding activity of the naturally occurring (S)-enantiomer demonstrates greater affinity toward ERβ while the (R)-enantiomer demonstrates greater affinity towards Erα.2,3 It displays protective effects in various cellular systems4,5 and may be useful in treatment of menopausal symptoms6.

References/Citations:

  1. Kim et al. (2026), Microbial Production and Industrial Applications of (S)-Equol for Precision Health and Functional Food Innovation; J.  Agric. Food Chem. 74 1938
  2. Setchell et al., (2005), S-equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora; Am.  J. Clin. Nutr. 81 1072
  3. Muthyala et al. (20o4), Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta; Bioorg. Med. Chem. 12 1559
  4. Richardson and Simpkins (2012), R- and S-equol have equivalent cytoprotective effects in Friedreich’s ataxia; BMC Pharmacol. Toxicol. 13 12
  5. Lephart et al. (2013), Protective effects of equol and their polyphenolic isomers against dermal aging: microarray/protein evidence with clinical implications and unique delivery into human skin; Pharm. Biol. 51 1393
  6. Chen and Chen. (2021), Utilization of Isoflavones in Soybeans for Women with Menopausal Syndrome: An Overview; Int. J. Mol. Sci. 22 3212
(S)-Equol, (S)-Equol supplier, 531-95-3, Equol supplier
CAS:
531-95-3
Catalog Number:
10-3718
Activity:
Phytoestrogen
Chemical Names:
(S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol
Alternate Name:
(S)-4',7-Isoflavandiol
Molecular Weight:
242.27
Molecular Formula:

C15H14O3

Solubility:
Soluble in DMSO (200 mg/ml)
Physical Properties:
White to off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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(S)-Equol (531-95-3) is a phytoestrogen produced via metabolic transformation of the isoflavonoid daidzein by human intestinal microflora.1 The estrogen receptor (ER) binding activity of the naturally occurring (S)-enantiomer demonstrates greater affinity toward ERβ while the (R)-enantiomer demonstrates greater affinity towards Erα.2,3 It displays protective effects in various cellular systems4,5 and may be useful in treatment of menopausal symptoms6.

References/Citations:

  1. Kim et al. (2026), Microbial Production and Industrial Applications of (S)-Equol for Precision Health and Functional Food Innovation; J.  Agric. Food Chem. 74 1938
  2. Setchell et al., (2005), S-equol, a potent ligand for estrogen receptor β, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora; Am.  J. Clin. Nutr. 81 1072
  3. Muthyala et al. (20o4), Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta; Bioorg. Med. Chem. 12 1559
  4. Richardson and Simpkins (2012), R- and S-equol have equivalent cytoprotective effects in Friedreich’s ataxia; BMC Pharmacol. Toxicol. 13 12
  5. Lephart et al. (2013), Protective effects of equol and their polyphenolic isomers against dermal aging: microarray/protein evidence with clinical implications and unique delivery into human skin; Pharm. Biol. 51 1393
  6. Chen and Chen. (2021), Utilization of Isoflavones in Soybeans for Women with Menopausal Syndrome: An Overview; Int. J. Mol. Sci. 22 3212

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